Sirona Biochem CEO’s Report on Progress
Momentum Public Relations
Press Release: September 21, 2017
VANCOUVER, BC–(Marketwired – September 21, 2017) – Sirona Biochem Corp. (TSX VENTURE: SBM) (FRANKFURT: ZSB) is pleased to provide a corporate update.
Dear Shareholders,
I would like to thank you for your continued support while we work through the negotiations for our skin lightener. The following is an update on our progress to date.
Skin Lightener, TFC-1067
We are pleased to announce that we have exchanged term sheets and advanced negotiations are ongoing with potential global partners. We will update our shareholders immediately upon any material change in the status of negotiations.
SGLT2 Inhibitor, SBM-TFC-039 (Wanbang)
Wanbang Biopharmaceuticals provided a progress report on the IND (Investigational New Drug) package that will go to the China Food and Drug Administration (CFDA). In vivo studies show that the SGLT2 Inhibitor significantly lowered blood glucose levels.
Further in vivo and in vitro studies, including toxicology, are wrapping up now and results are expected by November. CMC (chemistry, manufacturing and control) studies on pharmaceutical grade batch preparations are complete and have met reference standards for use in clinical studies.
Wanbang expects to file the IND to the CFDA by the end of this year. This will trigger another milestone payment of $500,000 USD to Sirona.
Recently, the Indian subsidiary of a global pharmaceutical company has expressed interest in licensing SBM-TFC-039 for India and have begun due diligence.
Cell Preservation and Anti-Aging (Glycoprotein) Library
In December 2016, we concluded testing of our glycoprotein compound library. Studies were successful in showing efficacy against various stressors in skin cells. There are many potential commercial applications of these compounds and interested partners requested a better understanding of the mechanism of action. We decided to go back to testing and do a full genomic study. These results will show us the pathways being affected within the cells and enable us to develop a more complete package of information for prospective companies. We are currently waiting for the report and anticipate receiving it early October 2017.
Acne Compound
Several of the compounds have completed chemistry and we will begin preclinical testing in Q4 2017. This was moved out slightly from mid-2017 due to chemistry process optimization.
Keloid Compound
We are working to put in place a Contract Research Organization (CRO) based in Europe with expertise in Keloid research to assist us. This has been delayed due to resource allocation.
Skin Lightener, TFC-849 (Valeant)
Our skin lightener asset, TFC-849, will be transferred with the sale of Obagi to Haitong International Zhonghua Finance Acquisition Fund I LP. The transaction is expected to be completed this year and we are continuing to work with Valeant during the transition. Limited partners of the fund include China Regenerative Medicine International Ltd. CRMI is a public company, traded on the Hong Kong stock exchange and currently focuses on three major business segments: tissue engineering, cell therapy, and cosmetics. With a China based company, they are well positioned to enter the skin lightening market.
Again, we thank you for your continued support and patience during this time.
Sincerely,
Dr. Howard Verrico, CEO
Sirona Biochem cautions you that statements included in this press release that are not a description of historical facts may be forward-looking statements. Forward-looking statements are only predictions based upon current expectations and involve known and unknown risks and uncertainties. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of release of the relevant information, unless explicitly stated otherwise. Actual results, performance or achievement could differ materially from those expressed in, or implied by, Sirona Biochem’s forward-looking statements due to the risks and uncertainties inherent in Sirona Biochem’s business including, without limitation, statements about: the progress and timing of its clinical trials; difficulties or delays in development, testing, obtaining regulatory approval, producing and marketing its products; unexpected adverse side effects or inadequate therapeutic efficacy of its products that could delay or prevent product development or commercialization; the scope and validity of patent protection for its products; competition from other pharmaceutical or biotechnology companies; and its ability to obtain additional financing to support its operations. Sirona Biochem does not assume any obligation to update any forward-looking statements except as required by law.
For more information regarding this press release, please contact:
Christopher Hopton
CFO
Sirona Biochem Corp.
Phone: 1.604.282.6064
Email: chopton@sironabiochem.com
- Published in Bio technology, Life Sciences, News Home, Sirona Biochem
Sirona Biochem Announces Resignation of Board Director
Momentum Public Relations
Press Release: September 13, 2017
VANCOUVER, BC–(Marketwired – September 13, 2017) – Sirona Biochem Corp. (TSX VENTURE: SBM) (FRANKFURT: ZSB) (XETRA: ZSB) announced today the resignation of Dr. Martin Gleave from the board of directors. Dr. Gleave is involved in a new venture that could result in a potential conflict. Accordingly both Dr. Gleave and the Company felt a resignation was most appropriate.
“We’d like to thank Dr. Gleave for his contribution to our company,” said Dr. Howard Verrico, CEO. “We wish him well in his future endeavors.”
About Sirona Biochem Corp.
Sirona Biochem is a cosmetic ingredient and drug discovery company with a proprietary platform technology. Sirona specializes in stabilizing carbohydrate molecules with the goal of improving efficacy and safety. New compounds are patented for maximum revenue potential.
Sirona’s compounds are licensed to leading companies around the world in return for licensing fees, milestone fees and ongoing royalty payments. Sirona’s laboratory, TFChem, is located in France and is the recipient of multiple French national scientific awards and European Union and French government grants. For more information, please visit www.sironabiochem.com.
Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.
Sirona Biochem cautions you that statements included in this press release that are not a description of historical facts may be forward-looking statements. Forward-looking statements are only predictions based upon current expectations and involve known and unknown risks and uncertainties. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of release of the relevant information, unless explicitly stated otherwise. Actual results, performance or achievement could differ materially from those expressed in, or implied by, Sirona Biochem’s forward-looking statements due to the risks and uncertainties inherent in Sirona Biochem’s business including, without limitation, statements about: the progress and timing of its clinical trials; difficulties or delays in development, testing, obtaining regulatory approval, producing and marketing its products; unexpected adverse side effects or inadequate therapeutic efficacy of its products that could delay or prevent product development or commercialization; the scope and validity of patent protection for its products; competition from other pharmaceutical or biotechnology companies; and its ability to obtain additional financing to support its operations. Sirona Biochem does not assume any obligation to update any forward-looking statements except as required by law.
For more information regarding this press release, contact:
Christopher Hopton
CFO
Sirona Biochem Corp.
Phone: 1.604.282.6064
Email: chopton@sironabiochem.com
- Published in Bio technology, Life Sciences, News Home, Sirona Biochem, Technology
Sirona Biochem Receives TSX Venture Exchange Approval on Warrant Extension
Sirona Biochem Receives TSX Venture Exchange Approval on Warrant Extension
Momentum Public Relations
Press Release: August 23, 2017
VANCOUVER, BC–(Marketwired – August 23, 2017) – Sirona Biochem Corp. (TSX VENTURE: SBM) (FRANKFURT: ZSB), announces an extension to the term of 8,850,770 common share purchase warrants (the “Warrants”) originally issued on March 6, 2014. The warrants were issued as part of a private placement. The expiry dates will be extended as follows:
March 6, 2014 | |
Number of Warrants: | 8,850,770 |
Original Expiry Date of Warrants: | March 6, 2017 |
New Expiry Date of Warrants: | November 30, 2017 |
Exercise Price of Warrants: | $0.25 |
All other terms of the Warrants will remain unchanged.
Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.
For more information regarding this press release, please contact:
Christopher Hopton
CFO
Sirona Biochem Corp.
Phone: 1.604.282.6064
Email: chopton@sironabiochem.com
- Published in Bio technology, Life Sciences, News Home, Sirona Biochem, Technology
Sirona Biochem Announces Positive Efficacy Results for Skin Lightening Library
Sirona Biochem Announces Positive Efficacy Results for Skin Lightening Library
Momentum Public Relations
Press Release: July 6, 2017
VANCOUVER, BC–(Marketwired – July 06, 2017) – Sirona Biochem Corp. (TSX VENTURE: SBM) (FRANKFURT: ZSB)(XETRA: ZSB) (the “Company“) announced positive preclinical efficacy data for its library of skin lightening compounds.
The study was conducted at Bioalternatives in France, a contract research organization specializing in cellular and molecular pharmacology. The study looked at each of six compounds’ ability to inhibit melanin synthesis induced by L-tyrosine for 10 days in normal human epidermal melanocytes. Results showed a significant decrease in melanin synthesis with a similar efficacy across the library. Inhibiting melanin production is the principal mechanism of action for the majority of skin lighteners in clinical use.
“In December 2016, we announced the completion of our skin lightening library, with plans to begin testing in 2017,” said Dr. Howard Verrico, CEO. “The positive efficacy of these compounds adds value to a licensing transaction as it increases the opportunity for commercialization in various markets and therapeutic areas. Moreover, this data will be used to support and strengthen our IP in this area.”
Sirona has shared these results with the multinational companies currently working towards a license to commercialize TFC-1067.
About Sirona Biochem Corp.
Sirona Biochem is a cosmetic ingredient and drug discovery company with a proprietary platform technology. Sirona specializes in stabilizing carbohydrate molecules with the goal of improving efficacy and safety. New compounds are patented for maximum revenue potential.
Sirona’s compounds are licensed to leading companies around the world in return for licensing fees, milestone fees and ongoing royalty payments. Sirona’s laboratory, TFChem, is located in France and is the recipient of multiple French national scientific awards and European Union and French government grants. For more information, please visit www.sironabiochem.com.
Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.
Sirona Biochem cautions you that statements included in this press release that are not a description of historical facts may be forward-looking statements. Forward-looking statements are only predictions based upon current expectations and involve known and unknown risks and uncertainties. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of release of the relevant information, unless explicitly stated otherwise. Actual results, performance or achievement could differ materially from those expressed in, or implied by, Sirona Biochem’s forward-looking statements due to the risks and uncertainties inherent in Sirona Biochem’s business including, without limitation, statements about: the progress and timing of its clinical trials; difficulties or delays in development, testing, obtaining regulatory approval, producing and marketing its products; unexpected adverse side effects or inadequate therapeutic efficacy of its products that could delay or prevent product development or commercialization; the scope and validity of patent protection for its products; competition from other pharmaceutical or biotechnology companies; and its ability to obtain additional financing to support its operations. Sirona Biochem does not assume any obligation to update any forward-looking statements except as required by law.
For more information regarding this press release, please contact:
Christopher Hopton
CFO
Sirona Biochem Corp.
Phone: 1.604.282.6064
Email: chopton@sironabiochem.com
- Published in Life Sciences, News Home, Sirona Biochem
The Fountain of Youth May Be Just Around the Corner In Vancouver
The Fountain of Youth May Be Just Around the Corner In Vancouver
Sirona Biochem makes safer and more effective cosmeceuticals
Vancouver-based Sirona Biochem is on track to crack the global market for skin lightening products, a market that has been predicted by Global Industry Analysts to hit US$23 billion by 2020. If that isn’t enough the company is also developing a product designed to forestall facial aging. Zion Market Research pegs the global anti-aging market at US$216.52 billion by 2021. The Company’s skin lightening products are far safer and far more effective than those which are currently on the market.
In hindsight it is not that surprising that Vancouver is becoming a hotbed of discovery when it comes to turning back the ravages of time. Botox as we know it today for the cosmetics industry, after all, was popularized in Vancouver by the husband and wife team of ophthalmologist Jean Carruthers and dermatologist Alistair Carruthers. They discovered that a toxin named botox helped eradicate the lines and wrinkles caused by aging.
Sirona Biochem Corp. (TSX-V:SBM) is a discovery and development stage biochem company that has developed a proprietary way to treat carbohydrate molecules using fluorination chemistry. This process prevents molecules from breaking down when exposed to enzymes. This now opens the door to developing a new field of therapeutics.
The company also has an anti-aging product based on synthesizing the glycoprotein found in the blood serum of Antarctic water fish and is currently in the testing and validation stage. The glycoprotein helps preserve the fish and its cells from the freezing water. When applied to humans, it helps prevent skin cells from dying, and also protects them from the harsh glare of ultra-violet radiation.
The good news for Sirona, however, doesn’t stop there. The company believes their stabilized carbohydrate molecules have applications in the treatment of cancer, pain, diabetes and inflammation. Sirona has developed an SGLT2 inhibitor as a Type 2 Diabetes treatment. Research and consulting firm Global Data has predicted that the global type 2 diabetes market will almost double from US$31.2 billion in 2015 to US58.7 billion by 2025.
SGLT2 inhibitors are a recent development in the fight against Type 2 diabetes. Most traditional diabetes treatments work by controlling insulin production or regulating blood sugar levels. SGLT2 inhibitors work by acting in the kidneys to reduce the reabsorption of glucose into the bloodstream.
Sirona’s strategy is to do the basic discovery and development work on a given product, and then to license the technique or joint venture it for commercialization, marketing and distribution. In 2014 the company signed a licensing agreement with Wanbang Biopharmaceuticals for the Chinese market. Wanbang will develop and commercialize Sirona’s SGLT2 inhibitor exclusively in the People’s Republic of China. The company also has a licensing agreement with Obagi Medical Products for a skin lightening agent.
Sirona Biochem was founded in 2009 by CEO Dr. Howard Verrico. The first thing Verrico did was to acquire the exclusive global license from TFChem for its proprietary SGLT2 Inhibitor. TFChem is based in Rouen, France. Verrico thought enough of TFChem’s research that he then went on to acquire TFChem as a wholly-owned subsidiary from its founder Dr. Geraldine Deliencourt-Godefroy. She then became Sirona’s Chief Science Officer and largest shareholder. TFChem now acts as Sirona’s research and development laboratory. A respected scientist, Deliencourt-Godefroy has also received a variety of honours in France including the acclaimed Francinov Research and Innovation Medal, the French Ministry of Research Award and the French Senate Award.
The company sees the cosmetic and cosmeceutical industry as its first major market penetration target for two important reasons. The first is that, as noted above, the financial reward for creating a fountain of youth will be immense. Secondly, the amount of regulatory testing for cosmetics is miniscule when compared to that involved in the pharmaceutical industry. The company intends to use the cash flow created by its anti-aging platform and skin colour lightening products, to finance the creation of more traditionally flavoured therapies for things like cell preservation and anti-inflammatories.
The company’s development focus is based on three high-return fields of discovery and development:
- Therapeutics: diabetes, anti-inflammatories and anti-infectives
- Cosmeceuticals: anti-aging and depigmenting agents
- Biological Ingredients: inducers and adjuvants for biological development and preservation.
With an SLGT2 inhibitor in the pre-clinical stage and four cosmetic products in the testing and validation phase, the company has received revenues and will continue to do so in the future from Wanbang for its SLGT2 inhibitor. Sirona also receives revenue from Obagi Medical products for a skin lightener, one of three skin lightening agents under development. It is also working on an acne treatment, an anti-inflammatory and an anti-infective.
Much of Sirona’s work is ground-breaking. Stabilizing carbohydrate molecules opens up new fields for therapeutic interventions and may rejuvenate older treatments which became stalled. Synthesizing the glycoprotein found in the blood serum of Antarctic fish may produce a product that slows down the aging of skin. One way to illustrate its potential value is that when TFChem first synthesized the glycoprotein, cosmetic giant L’Oreal Group, the world’s largest cosmetics company slapped a field-of-use patent on it. As it turns out the first synthesis was not stable, but the later ones were, and L’Oreal was out of luck.
While Sirona is concentrating on developing cosmetic products, it hasn’t neglected the medical side of things. The company has a pipeline of products that are heading towards the market. The anti-aging compound is now in the testing and validation phase.
The company has a 52-week high of $0.20 and a 52-week low of $0.12. As of June 16, 2017, it was trading at $0.17. And if you were wondering, Sirona is the name of the Celtic goddess of healing.
- Published in Bio technology, Blog, Sirona Biochem, Technology
Sirona Biochem Closes Convertible Note Financing
Sirona Biochem Closes Convertible Note Financing
Momentum Public Relations
Press Release: June 5, 2017
VANCOUVER, BC–(Marketwired – June 05, 2017) – Sirona Biochem Corp. (TSX VENTURE: SBM) (FRANKFURT: ZSB)(XETRA: ZSB) is pleased to announce that it has closed the non-brokered private placement (the “Private Placement”) of convertible notes (“Notes”). The financing was oversubscribed, resulting in gross proceeds of $587,000. Each Note is convertible at the option of the holder into one common share of the company at a conversion price of $0.18 per share.
The Notes will mature in 18 months from the date of issuance and bear interest at the rate of 12{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} per annum, payable quarterly, until the Notes are converted or repaid. The company will be entitled to repay the principal amount of the Notes, together with accrued and unpaid interest, at any time commencing four months after the date of issuance, subject to giving the holders prior notice thereof to permit holders to convert during the notice period.
All securities issued in connection with the private placement will be subject to a statutory hold period expiring on October 5, 2017.
About Sirona Biochem Corp.
Sirona Biochem is a cosmetic ingredient and drug discovery company with a proprietary platform technology. Sirona specializes in stabilizing carbohydrate molecules with the goal of improving efficacy and safety. New compounds are patented for maximum revenue potential.
Sirona’s compounds are licensed to leading companies around the world in return for licensing fees, milestone fees and ongoing royalty payments. Sirona’s laboratory, TFChem, is located in France and is the recipient of multiple French national scientific awards and European Union and French government grants. For more information, please visit www.sironabiochem.com.
Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.
Sirona Biochem cautions you that statements included in this press release that are not a description of historical facts may be forward-looking statements. Forward-looking statements are only predictions based upon current expectations and involve known and unknown risks and uncertainties. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of release of the relevant information, unless explicitly stated otherwise. Actual results, performance or achievement could differ materially from those expressed in, or implied by, Sirona Biochem’s forward-looking statements due to the risks and uncertainties inherent in Sirona Biochem’s business including, without limitation, statements about: a third party potential licensees of TFC-1067 may not deliver a term sheet to the company in Q1 2017 or at all; the company may not be able to negotiate a license agreement with a potential licensees of TFC-1067 on terms acceptable to Sirona Biochem; the progress and timing of its clinical trials are uncertain; difficulties or delays in development, testing, obtaining regulatory approval, producing and marketing products; unexpected adverse side effects or inadequate therapeutic efficacy of the company’s or licensed products that could delay or prevent product development or commercialization; the scope and validity of patent protection for the company’s or licensed products; competition from other pharmaceutical or biotechnology companies; and its ability to obtain additional financing to support its operations. Sirona Biochem does not assume any obligation to update any forward-looking statements except as required by law.
For more information regarding this press release, please contact:
Christopher Hopton
CFO
Sirona Biochem Corp.
Phone: 1.604.282.6064
Email: chopton@sironabiochem.com
- Published in Bio technology, News Home, Sirona Biochem, Technology
Sirona Biochem Announces Convertible Note Financing
Sirona Biochem Announces Convertible Note Financing
Momentum Public Relations
Press Release: May 31, 2017
VANCOUVER, BC–(Marketwired – May 31, 2017) – Sirona Biochem Corp. (TSX VENTURE: SBM) (FRANKFURT: ZSB)(XETRA: ZSB) announced today a non-brokered private placement (the “Private Placement”) of convertible notes (“Notes”) for gross proceeds of up to $500,000. Each Note will be convertible at the option of the holder into one common share of the company at a conversion price of $0.18 per share during the 18 month term of the Notes.
The Notes will mature in 18 months from the date of issuance and bear interest at the rate of 12{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} per annum, payable quarterly, until the Notes are converted or repaid. The company will be entitled to repay the principal amount of the Notes, together with accrued and unpaid interest, at any time commencing four months after the date of issuance, subject to giving the holders prior notice thereof to permit holders to convert during the notice period. The Notes are unsecured and transferable, subject to resale restrictions under applicable securities laws and TSX Venture Exchange requirements.
All securities issued in connection with the private placement will be subject to a statutory hold period of four months commencing from the date of issuance of the Notes. Closing of the private placement is subject to customary conditions, including TSX Venture Exchange acceptance.
This news release does not constitute an offer to sell or a solicitation of an offer to buy nor shall there be any sale of any of the Shares in any jurisdiction in which such offer, solicitation or sale would be unlawful. The Shares have not been and will not be registered under the United States Securities Act of 1933, as amended (the “U.S. Securities Act”) or any state securities laws and may not be offered or sold within the United States or to, or for the benefit of, U.S. persons (as defined in Regulation S under the U.S. Securities Act) unless registered under the U.S. Securities Act and applicable state securities laws or pursuant to an exemption from such registration requirements.
About Sirona Biochem Corp.
Sirona Biochem is a cosmetic ingredient and drug discovery company with a proprietary platform technology. Sirona specializes in stabilizing carbohydrate molecules with the goal of improving efficacy and safety. New compounds are patented for maximum revenue potential.
Sirona’s compounds are licensed to leading companies around the world in return for licensing fees, milestone fees and ongoing royalty payments. Sirona’s laboratory, TFChem, is located in France and is the recipient of multiple French national scientific awards and European Union and French government grants. For more information, please visit www.sironabiochem.com.
Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.
Sirona Biochem cautions you that statements included in this press release that are not a description of historical facts may be forward-looking statements. Forward-looking statements are only predictions based upon current expectations and involve known and unknown risks and uncertainties. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of release of the relevant information, unless explicitly stated otherwise. Actual results, performance or achievement could differ materially from those expressed in, or implied by, Sirona Biochem’s forward-looking statements due to the risks and uncertainties inherent in Sirona Biochem’s business including, without limitation, statements about: a third party potential licensees of TFC-1067 may not deliver a term sheet to the company in Q1 2017 or at all; the company may not be able to negotiate a license agreement with a potential licensees of TFC-1067 on terms acceptable to Sirona Biochem; the progress and timing of its clinical trials are uncertain; difficulties or delays in development, testing, obtaining regulatory approval, producing and marketing products; unexpected adverse side effects or inadequate therapeutic efficacy of the company’s or licensed products that could delay or prevent product development or commercialization; the scope and validity of patent protection for the company’s or licensed products; competition from other pharmaceutical or biotechnology companies; and its ability to obtain additional financing to support its operations. Sirona Biochem does not assume any obligation to update any forward-looking statements except as required by law.
For more information regarding this press release, please contact:
Christopher Hopton
CFO
Sirona Biochem Corp.
Phone: 1.604.282.6064
Email: chopton@sironabiochem.com
- Published in Bio technology, News Home, Sirona Biochem, Technology
Sirona Biochem (SBM:tsxv) Announces Keloid Data Accepted for Presentation to the Society of Investigative Dermatology
Sirona Biochem Announces Keloid Data Accepted for Presentation to the Society of Investigative Dermatology (SID)
Sirona Biochem Corp. (TSX VENTURE: SBM) (FRANKFURT: ZSB) (XETRA: ZSB) (the “Company“) announced today that it has been accepted to present recent data at the 76th Annual Society of Investigative Dermatology (SID) Meeting, April 26-29 in Portland, Oregon. Sirona’s abstract, titled, Novel glycopeptide potential in keloid formation prevention and recurrence, will be presented as a poster during the 4-day conference.
The presentation outlines initial study results on the compound KEL-01. KEL-01 has been tested on normal human dermal fibroblasts (NF) and keloid fibroblasts (KF) for gene expression and protein expression.
In NF gene expression, KEL-01 downregulated genes involved in extracellular matrix (ECM) synthesis, collagen I, III and elastin, while it upregulated genes involved in ECM degradation, namely MMP1 and MMP3. In protein expression studies, the addition of KEL-01 significantly decreased the levels of collagen I and collagen III in KF. When KEL-01 was added to the KF, the ratio of collagen I/III was regulated to that of NF. An additional assay done showed activation of the Nrf2 pathway via KEL-01, which is down-regulated in keloids.
“We are pleased with the early results of KEL-01 on keloid fibroblasts,” said Dr. Howard Verrico, CEO. “Keloid scars are difficult to treat and there remains a significant unmet need for those prone to their development. We are planning studies on this compound in more advanced scar models.”
About the 76th Annual SID Meeting
The Society for Investigative Dermatology was founded in 1937 to highlight and promote discovery in investigative dermatology and to better represent skin-related scientific investigation amongst medical societies. Soon after, they launched the Journal of Investigative Dermatology (JID), a source for all advancements in cutaneous biology. The first Annual Meeting was held in New York City in 1938.
The 76th Annual Meeting, like those before it, will bring together researchers, lecturers, and industry leaders in dermatology. Throughout the four-day conference, cutting-edge research, findings and trends in skin health and disease will be shared. All abstracts will be published in upcoming editions of the JID.
Alongside lectures from leading experts in the field and poster presentations, there will be opportunities to talk to representatives from global companies about partnerships and collaborations.
For more information, please visit the conference website at http://www.sidnet.org/.
About Sirona Biochem Corp.
Sirona Biochem is a cosmetic ingredient and drug discovery company with a proprietary platform technology. Sirona specializes in stabilizing carbohydrate molecules with the goal of improving efficacy and safety. New compounds are patented for maximum revenue potential.
Sirona’s compounds are licensed to leading companies around the world in return for licensing fees, milestone fees and ongoing royalty payments. Sirona’s laboratory, TFChem, is located in France and is the recipient of multiple French national scientific awards and European Union and French government grants. For more information, please visit www.sironabiochem.com.
Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.
- Published in Bio technology, Life Sciences, News Home, Sirona Biochem
Rising Popularity of Anti-Wrinkle Products Fuels Asia, Europe, and South America Anti-Aging Market
Rising Popularity of Anti-Wrinkle Products Fuels Asia, Europe, and South America Anti-Aging Market
This press release was orginally distributed by SBWire
Albany, NY — (SBWIRE) — 02/13/2017 — A new Transparency Market Research report states that the Asia, Europe, and South America anti-aging market was valued at US$15.3 bn in 2012 and is predicted to reach US$30.9 bn in 2020. It is expected to expand at a CAGR of 9.30{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} from 2014 to 2020. The title of the report is “Asia, Europe, and South America Anti-aging Market – Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 – 2020”.
Obtain the Sample Report of Asia, Europe, and South America Anti-Aging Market at: http://www.transparencymarketresearch.com/sample/sample.php?flag=S&rep_id=5021
As per the report, the anti-aging market in Asia, Europe, and South America is majorly fuelled by the increasing number of baby boomers, thus increasing the demand for various methods of curbing and reversing the prominent signs of aging. The market is continuously growing and a number of products, devices, and services have entered the market in recent years due to the consistent demand to lessen the signs of aging. Amongst these, in 2013, the anti-aging products held the biggest share in the anti-aging market due to increasing awareness amongst people and the economical prices of these products.
On the basis of product type, the market is segmented into dermal fillers, UV absorbers, botox, anti-stretch products, anti-wrinkle products, and hair color. Amongst these, in 2013, anti-wrinkle products held the biggest share in the anti-aging products market in Asia. The anti-wrinkle product segment stood at more than US$8.1 bn in Asia in 2013. This is due to the broad range of anti-wrinkle products available in the market and the rising awareness owing to a number of promotional campaigns held in Asia. Anti-wrinkle products also held the largest share in Europe in the same year. The demand for these products is high in European countries owing to their increasing availability at economical prices.
On the basis of service, the market is segmented into anti-adult acne therapy, anti-pigmentation therapy, liposuction, chemical peel, abdominoplasty, hair restoration therapy, sclerotherapy, and eyelid surgery. The anti-aging services market is expanding swiftly in Europe on account of the rising disposable income of consumers owing to ongoing recovery from the economic crisis in Europe. Within Europe, the anti-aging services market in Italy held the biggest share in 2013 owing to increasing demand for hair restoration treatments and breast augmentation. The anti-aging services market is predicted to record the highest growth rate in Spain in the forecast horizon due to the rising aging population and the increasing prevalence of obesity.
Read the Current Market Analysis of Asia, Europe, and South America Anti-aging at: http://www.transparencymarketresearch.com/asia-europe-south-america-anti-aging-market.html
On the basis of device type, the market is segmented into microdermabrasion devices, anti-cellulite treatment devices, radio frequency devices, and laser aesthetic devices. Anti-aging devices are the most prevalent in South American countries. Radiofrequency devices and laser aesthetic devices held the biggest share in South America, especially in Brazil, due to their high effectiveness and safety.Alma Laser Ltd., Allergan, Inc., Beiersdorf AG, Cynosure, Inc., Coty, Inc., L’Oreal SA, Valeant Pharmaceutical International, Inc., Solta Medical, Inc., and PhotoMedex, Inc., among others, are the major players dominant in the market.
About TMR
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The 2017 Standards of Medical Care in Diabetes: an update from the ADA
The 2017 Standards of Medical Care in Diabetes: an update from the ADA
The American Diabetes Association (ADA) has released the 2017 update to its Standards of Medical Care in Diabetes (Standards).1 The document is reviewed each year by a multidisciplinary committee of experts in diabetes care, which examines relevant research that informs the revisions.
“The most recent update to the ADA Standards of Medical Care addresses many new and important issues regarding the management of patients with diabetes,” said Kevin M. Pantalone, DO, staff endocrinologist and director of clinical research at the Cleveland Clinic Foundation. The 2017 Standards contain the usual guidelines pertaining to type 2 diabetes prevention and the diagnosis and treatment of type 1, type 2, and gestational diabetes. Additionally, Dr Pantalone identified several of the most notable updates.
One recommendation suggests considering metabolic surgery for patients with obesity and uncontrolled type 2 diabetes who have a body mass index (BMI) as low as 30 kg/m2 (27.5 kg/m2for Asian Americans). This update is based on a growing body of research showing that metabolic surgery — previously referred to as bariatric surgery — leads to improved glycemic control and reduced cardiovascular disease (CVD) risk in this patient population compared with other medical and lifestyle interventions.2 The committee also noted that the safety of metabolic surgery has significantly improved in the past 2 decades: Related mortality rates are 0.1{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} to 0.5{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce}, which are similar to the rates associated with hysterectomy or cholecystectomy.2
Another update recommends considering 2 specific glucose-lowering therapies (glucagon-like peptide-1 [GLP-1] receptor agonists or sodium-glucose cotransporter-2 [SGLT2] inhibitors) for high-risk patients with CVD who have type 2 diabetes, which is in line with the findings of recently published clinical trials, including the EMPA-REG OUTCOME (ClinicalTrials.gov identifier: NCT01131676) and LEADER (ClinicalTrials.gov identifier: NCT01179048) trials.
The EMPA-REG OUTCOME study examined the effects of the SGLT2 inhibitor empagliflozin vs placebo and usual care in high-risk patients with CVD who have diabetes.3 The findings show that the drug led to a 14{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} reduction in the composite outcome of myocardial infarction (MI) and stroke, and a 38{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} reduction in CV death over a median follow-up period of 3.1 years.3 As a result, the US Food and Drug Administration (FDA) added a new indication for empagliflozin to reduce CV mortality risk in adults with type 2 diabetes and heart disease.4 In a similar manner, results from the LEADER trial showed that the GLP-1 receptor agonist liraglutide resulted in fewer MI, stroke, or CV deaths compared with placebo (13{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} vs 14.9{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce}) over a median follow-up period of 3.8 years.5
The committee also sought to further define hypoglycemia. The update indicates that a level of lower than 54 mg/dL (3.0 mmol/L) should be considered serious, clinically important hypoglycemia, even in the absence of symptoms. It is recommended that values below this level be reported in clinical trials and practice. Previous recommendations defined hypoglycemia in hospitalized patients as blood glucose levels <70 mg/dL (3.9 mmol/L) and severe hypoglycemia as levels <40 mg/dL (2.2 mmol/L). Severe hypoglycemia is now defined as “that associated with severe cognitive impairment regardless of blood glucose level,” and a level ≤70 mg/dL “is considered an alert value and may be used as a threshold for further titration of insulin regimens,” according to the Standards.
“Also, and perhaps most important, is the Standards’ acknowledgment and addressing of the socioeconomic aspects of diabetes management: medication cost and self-management support,” Dr Pantalone added. “These areas had been inadequately addressed by earlier versions of the guideline.”
The new version includes 2 detailed tables that provide the estimated monthly cost of various glucose-lowering medications, and the section on reducing disparities in diabetes care states that community health workers, peers, and lay leaders can facilitate the delivery of diabetes self-management education (DSME) and support services. “Strong social support leads to improved clinical outcomes, a reduction in psychosocial issues, and adoption of healthier lifestyles,” the committee noted.
Other notable additions include recommendations pertaining to screening and mental health referrals for patients with depression, anxiety, diabetes distress, eating disorders, and other psychological issues; greater emphasis on assessing comorbidities in patients with diabetes, and an expanded list of such comorbidities, including mental disorders as well as autoimmune disease and HIV; a new physical activity recommendation to break up sedentary behavior every 30 minutes to reduce associated behaviors illuminated by recent research; and increased options for both glucose management and hypertension treatment.
“The ADA has done a fantastic job of remaining on top of the new advances in diabetes management, incorporating new findings and recommendations into the guidelines in a timely manner, but doing so only after a thorough and vigorous review of the recently published medical literature,” said Dr Pantalone.
References
- American Diabetes Association. Standards of medical care in diabetes–2017. Diabetes Care. 2017;40(Suppl. 1):S6-S10.
- Rubino F, Nathan DM, Eckel RH, et al. Metabolic surgery in the treatment algorithm for type 2 diabetes: a joint statement by international diabetes organizations. Diabetes Care. 2016;39(6):861-77.
- Zinman B, Wanner C, Lachin JM, et al; EMPA-REG OUTCOME Investigators. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med. 2015; 373:2117-2128.
- FDA approves Jardiance to reduce cardiovascular death in adults with type 2 diabetes [news release]. Silver Spring, MD: FDA; December 2, 2016. www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm531517.htm. Accessed January 18, 2017.
- Marso SP, Daniels GH, Brown-Frandsen K, et al.; LEADER Steering Committee; LEADER Trial Investigators. Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med. 2016;375:311-322.
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