InMed (IN:CSE) Updates Progress of its Epidermolysis Bullosa Program
InMed Updates Progress of its Epidermolysis Bullosa Program
– Momentum Public Relations – May 18th, 2016
InMed Pharmaceuticals Inc. (“InMed”) (CSE: IN; OTCQB: IMLFF), a biopharmaceutical company specializing in the research and development of novel, cannabinoid-based therapies is pleased to provide an update on the progress of INM-750, its lead product in development for epidermolysis bullosa (EB), a serious and severe genetically inherited skin disorder.
INM-750 is a topical formulation of phytocannabinoids that has been specifically designed to: (i) modify the underlying cause of the disease in patients with epidermolysis bullosa simplex (EBS, the most common form of the disease), and (ii) to treat the major symptoms of the disease in all patients with EB.
InMed is now pleased to report that INM-750 has demonstrated positive pain relieving effects in animal models. Dr. Sazzad Hossain, Chief Scientific Officer of InMed, stated, “I am very excited with these results as pain is a serious complication in EB and this animal data shows that INM-750 reduces both acute and chronic pain. Significant data has been previously generated and reported to demonstrate the diverse properties of INM-750 in wound healing, skin regeneration, anti-inflammation and its antibacterial effects. Together with pain, these disease hallmarks are key therapeutic targets for the effective treatment of EB as well as several other dermatological conditions.”
A summary of the pre-clinical results on INM-750, a non-THC cannabinoid based composition, is available on InMed’s website under the Investors and the Pipeline sections.
About Epidermolysis bullosa simplex (EBS)
Epidermolysis bullosa simplex (EBS) is one of the major forms of epidermolysis bullosa (EB), a group of genetic conditions that cause the skin to be very fragile and to blister easily. It is a result of a defect in anchoring between the epidermis and the dermis, resulting in severe skin fragility that can range from mild to lethal. There is no cure or approved treatments for EB. Wound care, pain management and preventative bandaging are currently the only options available.
About InMed
InMed is a preclinical stage biopharmaceutical company that specializes in developing novel therapies through the research and development into the pharmacology of cannabinoids combined with innovative drug delivery systems. InMed’s proprietary platform technology, product pipeline and accelerated development pathway are the fundamental value drivers of the company. For more information, visit www.inmedpharma.com.
- Published in InMed Pharmaceuticals, News Home
InMed’s (IN:CSE) INM-750 Shows Positive Effects on Wound Healing
InMed Provides Update on Progress of Its Development Program for Epidermolysis Bullosa
Including New Pre-clinical Results on the Wound Healing and Anti-inflammatory Properties of INM-750
InMed Pharmaceuticals Inc. (“InMed”) (IN:CSE)(IMLFF:OTCQB), a biopharmaceutical company specializing in the research and development of novel, cannabinoid-based therapies would like to provide an update on the progress of INM-750, its lead product in development for epidermolysis bullosa (EB), a serious and severe genetically inherited skin disorder.
INM-750 is a topical formulation of phytocannabinoids that have been carefully selected using our proprietary bioinformatics discovery platform to treat: (i) the underlying cause of the disease in patients with epidermolysis bullosa simplex (the most common form of the disease), and (ii) to treat the major symptoms of the disease in all patients with EB.
InMed’s initial pre-clinical studies were focused on studying the potential of INM-750 to treat the cause of the disease by modulating the expression of the various keratins that are critical to maintaining the integrity of the skin. We have previously reported that InMed has been able to demonstrate that certain phytocannabinoids are able to positively influence the expression of the key keratins K5, K6, K14, K15 and K16. We continue to make progress in studying the effect of different cannabinoids at different doses on keratin expression, and a summary of our initial results are now available on our website.
InMed is now pleased to report that INM-750 has demonstrated positive effects in pre-clinical studies on wound healing and in inflammation. InMed has been studying the potential of certain cannabinoids to expedite the wound healing process using the electric cell-substrate impedance sensing (ECIS) wounding assay. The ECIS wounding assay is a state-of-the-art assay that replaces the traditional scrape or scratch assay. Using this assay, InMed has been able to identify certain cannabinoids that significantly potentiate the wound healing process, when compared to other less active cannabinoids, or to the vehicle control. Dr. Sazzad Hossain, Chief Scientific Officer of InMed, stated, “The results we are obtaining with the ECIS wound assay are significant for the development of INM-750. Through the use of the ECIS assay we are able to demonstrate the wound healing and skin regeneration properties of INM-750; these properties will be critical to help alleviate the primary symptoms of patients with EB”.
In addition to the ECIS studies, InMed has also studied the anti-inflammatory effect of certain cannabinoids included in INM-750. It has been demonstrated that cannabinoids included in INM-750 are able to down regulate the production of IL-8 by human keratinocytes, and inhibit IFN╔ú/TNFΓì║ induced production of IL-6 by human keratinocytes. Dr. Sazzad states, “These results are important to demonstrate that in addition to having an effect on wound healing, the cannabinoids included in INM-750 should also help down regulate the chronic inflammation that is present in EB patients”.
InMed continues to develop INM-750 with the goal of entering the clinic in the first half of 2016. Initial proof of concept studies in human subjects should be completed by the end of 2016. Paul Brennan, CEO of InMed says “I am pleased with the progress of our development program, and the data that has been generated by Dr. Hossain and his colleagues. INM-750 has the potential to provide a significant addition to the treatment options for patients with EB and EBS.”
A summary of the pre-clinical results on INM-750 is available on InMed’s website under the Investors and the Pipeline sections.
About Epidermolysis bullosa simplex (EBS)
Epidermolysis bullosa simplex (EBS) is one of the major forms of epidermolysis bullosa (EB), a group of genetic conditions that cause the skin to be very fragile and to blister easily. It is a result of a defect in anchoring between the epidermis and the dermis, resulting in friction and skin fragility. The severity of this condition ranges from mild to lethal. There is no cure or approved treatments for EB. Wound care, pain management and preventative bandaging are currently the only options available.
About InMed
InMed is a preclinical stage biopharmaceutical company that specializes in developing novel therapies through the research and development into the pharmacology of cannabinoids combined with innovative drug delivery systems. InMed’s proprietary platform technology, product pipeline and accelerated development pathway are the fundamental value drivers of the company. For more information, visit www.inmedpharma.com.
- Published in Blog, Business, Medical Marijuana
InMed Pharma Starts Testing Drug Delivery System
InMed Commences Development of Proprietary Drug Delivery System
InMed Pharmaceuticals Inc. (“InMed”) (CSE: IN)(OTCQB: IMLFF) is pleased to announce it has initiated testing of a novel nanoparticle based delivery system for INM-750 which will be used for clinical formulations. INM-750 is a proprietary phytocannabinoid based compound for the treatment of epidermolysis bullosa simplex (EBS), a rare genetically inherited skin disorder (See NR News Release May 26, 2015 and August 6, 2015).
InMed’s development programs for transdermal delivery will use a nanoparticle-based delivery system. The delivery system underwent investigation in in vitro and in vivo animal models and further studies are being conducted based on the European norm “BS EN 13726-1: 2002” entitled test methods for wound dressings.
InMed anticipates commencing human proof of concept clinical studies of INM-750 in February, 2016 with initial data expected by Q3 2016 after which InMed will seek orphan drug designation for INM-750 with the US Food and Drug Administration (FDA).
About InMed
InMed is a clinical stage biopharmaceutical company that specializes in developing novel therapies through the research and development into the extensive pharmacology of cannabinoids coupled with innovative drug delivery systems. InMed’s proprietary platform technology, product pipeline and accelerated development pathway are the fundamental value drivers of the company.
For more information, visit www.inmedpharma.com.
- Published in Blog, Business, Life Sciences, Medical Marijuana
InMed Announces Positive In-Vitro Study Results
InMed Announces Positive In-Vitro Study Results of INM-750 Targeting Epidermolysis Bullosa Simplex (EBS)
InMed Pharmaceuticals Inc. (“InMed”) (CSE: IN)(OTCQB: IMLFF), a biopharmaceutical company specializing in the research and development of novel, cannabinoid-based therapies combined with innovative drug delivery systems, announced today that it has obtained positive response from its pre-clinical research on INM-750 tested in various in vitro assays. The INM-750 is a proprietary phytocannabinoid based compound for the treatment of epidermolysis bullosa simplex (EBS), a rare genetically inherited skin disorder. INM-750 is designed to modulate skin growth, differentiation and inflammation that are signature characteristics of EBS.
Dr. Sazzad Hossain, Chief Scientific Officer of InMed, stated, “There are different sub-types of EBS caused by mutations of various keratin genes such as keratin 5, keratin 14 or keratin 15 etc. By modulating the expression of various keratin genes that are responsible for cytoskeleton intermediate filaments and/or wound healing using INM-750, we hoped to alleviate the EBS symptoms. Our preliminary results clearly validate this approach since INM-750 displayed modulation of expression of various keratin genes.”
Craig Schneider says, “We are very pleased that we have again demonstrated the ability and efficiency of our platform technology (“IDP”) to discover novel therapies in disease areas with large unmet medical needs. We have successfully employed our “IDP” for the discovery of INM-750 (see News Release May 26, 2015) which validates our in-silico approach to drug discovery by these positive pre-clinical results.”
InMed anticipates commencing human proof of concept clinical studies of INM-750 in February, 2016 with initial data expected by Q3 2016 after which InMed will seek orphan drug designation for INM-750 with the US Food and Drug Administration (FDA).
About Epidermolysis bullosa simplex (EBS)
Epidermolysis bullosa simplex (EBS) is one of the major forms of Epidermolysis bullosa, a group of genetic conditions that cause the skin to be very fragile and to blister easily. It is a result of a defect in anchoring between the epidermis and dermis, resulting in friction and skin fragility. Its severity ranges from mild to lethal. As of today there is no cure or effective treatment. Currently, wound care, pain management and preventative bandaging are the only options available for treatment.
About InMed
InMed is a clinical stage biopharmaceutical company that specializes in developing novel therapies through the research and development into the extensive pharmacology of cannabinoids coupled with innovative drug delivery systems. InMed’s proprietary platform technology, product pipeline and accelerated development pathway are the fundamental value drivers of the company. For more information, visit www.inmedpharma.com.
- Published in Blog, Life Sciences
InMed applies to patent EPS treatment in U.S.
INMED PHARMACEUTICALS FILES PROVISIONAL PATENT COVERING NOVEL COMPOUNDS FOR TREATING EPIDERMOLYSIS BULLOSA SIMPLEX (EBS)
InMed Pharmaceuticals Inc. (“InMed”) (IN:CSE ; IMLFF:OTC), announced today that it has filed a provisional patent application with the United States Patent and Trademark Office (“USPTO”) relating to the treatment of Epidermolysis Bullosa Simplex (EBS) using novel formulations of natural cannabinoid compounds developed by InMed.
Dr. Sazzad Hossain, InMed Pharmaceuticals’ Chief Scientific Officer, commented, “We are excited to file our first patent covering the use of our products in a high-value orphan disease category. Based on preliminary studies, our compounds are expected to positively address the significant medical needs of EBS by promoting improvement of the key hallmarks of the disease (anti-itching, wound healing, anti-microbial, pain, anti-inflammation). We are continuing the process to build our IP within the dermatology area, adding further value to our pipeline of novel therapeutics.”
A provisional patent application is a legal document that establishes an early priority date for the benefit of claiming “first to file” status against other companies or individuals that may want to file for a patent with similar claims after the filing date of our provisional application.
About InMed
InMed is a clinical stage biopharmaceutical company that specializes in developing cannabis based therapies through the research and development into the extensive pharmacology of cannabinoids coupled with innovative drug delivery systems. InMed’s proprietary platform technology, product pipeline and accelerated development pathway are the fundamental value drivers of the Company.
- Published in Blog, Life Sciences