Lakeland Resources property agreement amended
The TSX Venture Exchange has accepted for filing an amendment to a property acquisition agreement dated March 25, 2012, between Lakeland Resources Inc., and Mike Tremblay and Mathieu Tremblay, whereby in lieu of the final payment of $15,000, the company will issue 100,000 common shares.
- Published in Mining
Saudis take up defense
Saudi Arabia is a target for both sides in Iraq’s deepening conflict, one reason it has ramped up security levels to confront a threat that’s more immediate than the Arab Spring revolts three years ago.
The world’s biggest oil exporter convened its national security council for a rare meeting under King Abdullah, and has bolstered defenses at the…
Saudi Arabia is a target for both sides in Iraq’s deepening conflict, one reason it has ramped up security levels to confront a threat that’s more immediate than the Arab Spring revolts three years ago.
The world’s biggest oil exporter convened its national security council for a rare meeting under King Abdullah, and has bolstered defenses at the border with Iraq, where militants last month seized several cities and declared an Islamic state. The king vowed to protect the nation’s “resources and territory and prevent any act of terror.”
For the 90-year-old monarch, the threat is twofold. Sunni militant groups, like the Islamic State led by Abu Bakr Al-Baghdadi that now controls parts of Iraq as well as Syria, have historically posed a challenge to the Al Saud family’s rule. Another danger comes from Shiite militias, which struck across the Saudi border in the past and are now being called to arms to help fight the insurgents.
“An al-Qaeda offshoot armed with heavy weaponry and flush with cash wreaking havoc a mere 100 miles from their border is not a dream scenario,” said Fahad Nazer, a political analyst at JTG Inc., a consultancy based in Vienna, Virginia. “It also doesn’t help that at least two Shiite militias have vowed to bring the war to Saudi Arabia.”
Ties between OPEC’s two largest oil producers have been strained since the U.S. invasion of Iraq in 2003.
No Embassy
As the region’s main Sunni power, Saudi Arabia has links with Iraq’s Sunni minority, who dominated the government before the fall of Saddam Hussein and now complain of discrimination under Prime Minister Nouri al-Maliki’s Shiite leadership. There’s no Saudi embassy in Baghdad, and little commercial contact.
The gap has grown wider with the recent violence.
Maliki last month accused Saudi Arabia of “siding with terrorism” by providing financial and moral support, and blamed the kingdom’s leaders for the Sunni insurgency in northern and western Iraq. Saudi Arabia replied that it’s at the “forefront of combating terrorism” and blamed Maliki’s “sectarian policies” for destabilizing Iraq.
The conflict has raised the risk of a civil war in Saudi Arabia’s neighbor. The Sunni militants have overrun Mosul, Iraq’s biggest northern city, as well as Saddam’s hometown of Tikrit. They’re also fighting for the nation’s biggest refinery in Baiji. The army said it foiled the latest attempt to seize the facility on July 4, killing all militants who took part.
Islamist ‘Epidemic’
As the Islamists advanced in Iraq, the benchmark Saudi stock index posted its first monthly drop since August. Oil prices jumped in the first days, with Brent crude reaching a nine-month high of $115.71 a barrel on June 19, before paring gains as the conflict spared Iraq’s main oil-producing region in the south. Saudi Arabia said it’s ready to respond to any supply shortage.
Official Saudi support for Iraq’s Sunnis doesn’t extend to extremists like the Islamic State, according to Gregory Gause, a professor of political science at the University of Vermont in Burlington and a specialist in Gulf politics. The group declared a caliphate on June 29 and said it was changing its name from the Islamic State in Iraq and the Levant, or ISIL.
Such organizations, including al-Qaeda, have attacked Saudi targets in the past, and accused the Al Sauds of collaborating with enemies of Islam through their alliance with the U.S. Saudi Foreign Minister Prince Saud al-Faisal has described the Islamic State as an “epidemic.”
Article source: http://feedproxy.google.com/~r/resourceinvestornews/~3/xUVShnmC-yc/saudis-take-up-defense
Read more http://financialpress.com/2014/07/08/saudis-take-up-defense/
- Published in Mining
Wonkbook: Washington’s legal marijuana policy experiment
1. Top story: Washington state’s experiment with legal recreational marijuana begins
Sales of recreational marijuana begin in Washington state. “Washington’s experiment with licensed, legal recreational marijuana began tentatively in a handful of places around the state on Tuesday, with limited supplies…but with great enthusiasm and hoopla in the places where the sales occurred.Where the experiment will lead after the novelty wears off remains deeply uncertain….Possessing marijuana in small amounts and consuming it at home has been legal in Washington for almost two years now…and local law enforcement agencies had mostly backed off enforcing marijuana laws before that. It had not, however, been legal to sell it for recreational purposes until Tuesday.” Kirk Johnson in The New York Times.
Explainer: How the recreational marijuana system in Washington state works. Katy Steinmetz in Time Magazine.
Chart: Where you can maybe buy recreational marijuana. German Lopez in Vox.
Slight problem: There’s a shortage of legal pot. “Although some of Denver’s marijuana shops ran out of product when they opened in January, the kind of shortages expected in Washington are above and beyond….The contrast speaks to just how varied different states’ experiences might be as they strive to legalize marijuana for recreational and medical purposes….Strangely enough, the lack of regulations on the medical marijuana system, which isn’t going through a shortage, could be the saving grace for Washington’s pot enthusiasts. Because the system is so unregulated, many of Washington’s marijuana users already have access to the drug through friends and medical dispensaries….The shortage might only affect curious newcomers and tourists.” German Lopez in Vox.
Interview: Why illegal/unlicensed pot dealers are freaking out. Matt Berman in National Journal.
Lessons from Colorado: A pot learning curve. “The two states have been under scrutiny as they embark on test cases in legalization, watched closely by everyone from legalization critics to advocates pushing legal marijuana in other states, including Oregon and Alaska. Observers are keeping tabs both on how smoothly the rollout goes, as well as looking to the differences in the two states’ approaches….The area of legalization under the most scrutiny in Colorado is the sale of ‘edibles.’…In response to Colorado’s experiences, Washington last month issued some new rules governing the packaging, labeling, and sale of edibles, and it has yet to issue a license for a kitchen to produce such products.” Amanda Paulson in The Christian Science Monitor.
Explainer: 7 differences between Colorado and Washington state’s recreational-marijuana systems. Trevor Hughes in USA Today.
It takes a lot to protect a pot shop. “To protect the people working, the pot and the profits, several layers of security are needed, he said. ‘You can’t cut in from above. You can’t tunnel in from below,’ said Davis, pointing to a maze of circuits on the ceiling. ‘The system will pick you up before you ever manage to get inside.’ Davis also has 14 high-definition, infrared cameras always rolling. Bullet-resistant glass is part of a demolition-resistant wall that customers first see after they walk through the front door. The facility is outfitted with motion sensors, heavy-duty locks and alarms.This, plus panic buttons for the workers, are what’s necessary to deal with cannabis in an all-cash environment, he said.” Natalie Swaby in KING-TV.
What’s the pot-shop experience like? “Seattle’s first pot shop, in an industrial district south of downtown, is no Starbucks. It’s on a busy six-lane road on which trucks frequently rumble by, and it has no off-street parking. The store’s name is in small print above the mailbox. Under state rules, cannabis can’t be displayed in windows and the stores can’t be near schools, playgrounds, libraries, or parks. Inside, glass jewelry cases once used in a Sears (SHLD) department store display pipes and bongs. The bright lights and wood laminate flooring call to mind an optometrist’s shop in a mall, except for the cash machine next to the register. There’s no place to comfortably sit; pot can’t be consumed on the premises.” Peter Robison in Bloomberg Businessweek.
Quotable: “It’s the quality. It’s like a candy store, like chocolates. You can never get enough.” — Deborah Greene, a customer at a new recreational-pot shop in Wash. state. Maria L. La Ganga in Los Angeles Times.
Whose pot is better: Washington’s or Colorado’s? It’s hard to say. “Retailers in Washington braced for long lines and high demand. The same happened when Colorado legalized recreational sales Jan. 1, and tens of thousands of buyers got the chance to pick from a wide variety of strains, from Blue Dream to AK-47 and Facewreck. Those names represent known genetic strains of marijuana plant — think Macintosh and Granny Smith apples — that are cultivated the world over. But even though the genetics are the same, how the plants are grown makes an enormous difference, experts say. That makes it all but impossible to make consistent comparisons.” Trevor Hughes in USA Today.
Explainer: A guide for recreational-marijuana shoppers. Trevor Hughes in USA Today.
Cuomo signs bill legalizing medical pot in N.Y. state. “The measure, which passed both houses of the legislature during the final moments of the legislative session, in June, is significantly more restrictive than other medical-marijuana laws in the nation.” Erica Orden in The Wall Street Journal.
Other legal reads:
Odd couple — Cory Booker, Rand Paul — team up on sentencing reform bill. Ed O’Keefe in The Washington Post.
Mob-busting tool used against online crime. Andrew Grossman in The Wall Street Journal.
Top opinion
PORTER: Blueprints for taming the climate crisis. “It offers a sobering conclusion. We might be able to pull it off. But it will take an overhaul of the way we use energy, and a huge investment in the development and deployment of new energy technologies. Significantly, it calls for an entirely different approach to international diplomacy on the issue of how to combat climate change….But despite these risks, the report offers a promising new path to overcome the decades-old logjam of climate change negotiations. For the first time, when we say we can stop the climate from heating we will more or less know what we are talking about.” Eduardo Porter in The New York Times.
McARDLE: Who’s the real Hobby Lobby bully? “I think…Hobby Lobby and Little Sisters of the Poor are obviously correct — they are being forced by the government to buy something that they don’t want to buy….If it weren’t for state power, the Little Sisters of the Poor would be happily not facilitating the birth-control purchases of its employees; the Barack Obama administration has attempted to force them to do otherwise….All this is old ground. The interesting question is why people on the other side view ceasing the coercion as itself coercive while arguing that the original law did not, in fact, force anyone to violate their religious beliefs.” Megan McArdle in Bloomberg View.
CHAIT: GOP after the apocalypse. “The reformicons’ retreat from Ryan-style apocalypticism is not only a shrewd tonal shift, but also a welcome — albeit unacknowledged — recognition that the party’s doomsaying has not come to pass, and that the American way of life will indeed survive Obama’s reforms. Indeed, the success of Obama’s domestic agenda may create more space for a conservative counteroffensive, in the way that Reaganism opened political room for Bill Clinton. Whether or not the reformicons ever compose a workable domestic agenda, they have come to recognize that they cannot run a presidential campaign promising to rescue America from fire and rubble visible only to themselves.” Jonathan Chait in New York Magazine.
KRUGMAN: Conservative delusions about inflation. “Confronted with a conflict between evidence and what they want to believe for political and/or religious reasons, many people reject the evidence. And knowing more about the issues widens the divide, because the well informed have a clearer view of which evidence they need to reject to sustain their belief system….I found myself thinking about the similar state of affairs when it comes to economics….And if you look at the internal dynamics of the Republican Party, it’s obvious that the currency-debasement, return-to-gold faction has been gaining strength even as its predictions keep failing. Can anything reverse this descent into dogma? A few conservative intellectuals have been trying to persuade their movement to embrace monetary activism, but they’re ever more marginalized.” Paul Krugman in The New York Times.
EDSALL: How much do our genes influence our political beliefs? “It’s been a key question of American politics since at least 1968: Why do so many poor, working-class and lower-middle-class whites — many of them dependent for survival on government programs — vote for Republicans? The debate over the motives of conservative low-income white voters remains unresolved, but two recent research papers suggest that the hurdles facing Democrats in carrying this segment of the electorate may prove difficult to overcome.” Thomas B. Edsall in The New York Times.
WEISER: Sharing the leverage. “In their new book House of Debt, economists Atif Mian and Amir Sufi connect the vast increase in consumer debt with the Great Recession and slow-motion recovery. But rather than sing a requiem for a half-century of proxy Keynesianism…they shout hosannas for even more debt….Complex and opaque debt structures enable politicians and crony capitalists to disguise high leverage while spinning the predictable blowups as black swan events. If a consumer debt hangover is hindering the economy, as Mian and Sufi plausibly argue, then the government should be encouraging writedowns in exchange for the elimination of future guarantees and other hidden debt subsidies. Borrowers and lenders, not taxpayers, should bear the risk.” Jay Weiser in National Review.
Animals interlude: Looks like Grumpy Cat has some company. “Purrmanently sad cat” looks adorably sad all the time.
2. Obama’s requests emergency-funding to deal with the migrant crisis
Obama’s border migrant-crisis funding request faces tough path on Capitol Hill. “Hours after the Obama administration requested $3.7 billion in emergency funding to address the current child immigration crisis at the southern border, few on Capitol Hill were predicting speedy passage — if at all — of legislation to provide Obama with the money he has requested. Instead, the conventional wisdom on the Hill among both Democrats and Republicans is the same as it has been for any number of issues this year — from minimum wage, to unemployment extension, to any number of jobs bills: probably not going to happen.” Wesley Lowery in The Washington Post.
Chart: A breakdown of the White House’s request. The Washington Post.
Border help for HHS, amid a potential new public-health crisis. “Those funds will help HHS provide ‘appropriate care’ for the children, who are mostly coming from El Salvador, Guatemala and Honduras….HHS is one of the agencies responsible for caring for the children, a little-known task that could prove arduous as the number of unaccompanied kids continues to surge. The department’s Unaccompanied Alien Children (UAC) program handled about 6,000 to 8,000 children a year between 2003 and 2011 while they were readied for deportation or took their cases to court. But a new wave of immigrants from Central America means the workload could soar to 90,000 unaccompanied kids this fiscal year and 127,000 in 2015, advocates told The Hill.” Ferdous Al-Faruque in The Hill.
U.N. urges U.S. to treat migrant children as refugees. “People who enter the U.S. and nearby countries illegally from El Salvador, Guatemala and Honduras should not be forced to return home and should be treated as refugees, a U.N. agency says. The U.N. High Commissioner for Refugees says people from those countries are subject to persecution….The call from the U.N. echoes statements made in the spring, when the refugee agency released ‘Children on the Run,’ a report that cited interviews with migrant children who had crossed international borders to flee violence. This week, the U.S. and its neighbors will hold meetings in Nicaragua to discuss ‘updating a 30-year-old declaration regarding the obligations nations have to aid refugees,’ the AP says.” Bill Chappell in NPR.
Obama will visit Perry, but not the border. What will they discuss? “President Barack Obama will meet Texas Governor Rick Perry on Wednesday to discuss a surge of Latin American young people crossing the U.S.-Mexico border that has put the two leaders at odds with each other. Perry’s office welcomed the meeting, to take place in Dallas on the governor’s turf, in a Tuesday statement that said they would discuss the humanitarian and national security crises along the southern border….But the White House said he would not visit the border, a sign that officials do not see a political upside.” Mark Felsenthal and Jon Hershkovitz in Reuters.
Other immigration reads:
Mark Zuckerberg’s immigration push hits brick wall. Jessica Meyers in Politico.
ALDEBOT-GREEN: America’s young refugees. “The president’s solution to change the law governing the processing of unaccompanied youth would be a disaster, particularly for youth who have valid immigration claims. For now, the White House has decided to separate its emergency funding request from these contentious policy changes in order to more carefully consider the competing needs of respecting due process and speeding up removal. This is a good and prudent start to setting better policy in a trying context. No doubt the United States is now facing a refugee crisis within its borders. Yet the administration should not bow to pressure simply to gain political cover. Rather, it should advance policies based on the principle that unaccompanied youth migration is a humanitarian crisis.” Scarlett Aldebot-Green in Foreign Policy.
Wonky caffeine interlude: What does it take to make a decent cup of coffee in space?
3. Improving your experience with your doctor
What are drug companies paying your doctor? You can find out soon. “The financial ties, which naturally raise conflict-of-interest concerns, aren’t always clear, but that’s about to change because of a lesser-known Obamacare provision. Some of the major drugmakers have been reporting some information about financial relationships with care providers — some voluntarily, some as the result of litigation — but a comprehensive nationwide effort is about to launch this summer, and the federal government is now looking to bring even greater transparency. Drug and device companies will now have to report to the government payments to doctors and teaching hospitals of at least $10 (or $100 over the year), and the Medicare agency will soon post the reports in a public database.” Jason Millman in The Washington Post.
Long wait times have become the norm. “One small consolation of our high-priced health care system — our $2.7 trillion collective medical bill — has been the notion that at least we get medical attention quickly. Americans look down on national health systems like Canada’s and Britain’s because of their notorious waiting lists. In recent weeks, the Veterans Affairs hospitals have been pilloried for long patient wait times, with top officials losing their jobs. Yet there is emerging evidence that lengthy waits to get a doctor’s appointment have become the norm in many parts of American medicine, particularly for general doctors but also for specialists. And that includes patients with private insurance as well as those with Medicaid or Medicare.” Elisabeth Rosenthal in The New York Times.
Doctors may soon be paid for not making you wait. “More doctor pay is being tied to patient satisfaction metrics, another sign health care may be coming more consumer-friendly, according to a new national analysis of physician compensation. Already, doctors and hospitals increasingly have more of their pay tied to health outcomes and related clinical measures as medical care moves toward value-based compensation rather than fees for service. But momentum is slowly building for physicians to also be measured on how quickly phone calls are returned to how long a patient sits in a physician office waiting area as part of ‘patient satisfaction metrics’ insurers are working into contracts with medical-care providers.” Bruce Japsen in Forbes.
Preventive services differ between primary care docs and OB/GYNs. “The services women receive during annual preventive care visits may partially depend on what type of doctor they see, suggests a new report. Women who saw primary care doctors for their annual checkup tended to receive a broader range of services, compared to those who saw obstetrician/gynecologists (OB/GYNs), researchers found.” Reuters.
Explainer: 4 medical tests that are awkward, embarrassing, and unnecessary. Sarah Kliff in Vox.
Other health care reads:
Smallpox vials found in storage room of NIH facility. Lena H. Sun and Brady Dennis in The Washington Post.
Without federal action, states move on long-term care. Michael Ollove in Pew Stateline.
U.S. Democrats aim to turn contraception into campaign drive. David Morgan in Reuters.
Food science interlude: The chemistry of why meat browns on the grill, or not.
4. Signs of promise on highway funding, Ex-Im Bank reauthorization
First, highway stopgap funding. “House Ways and Means Committee Chairman Dave Camp (R-Mich.) on Tuesday proposed a transfer of almost $20 billion from the general tax fund to help sustain transportation funding until next April….Without the transfer, federal officials have warned that money for the nation’s major transportation projects would begin to slow after Aug. 1 as the Highway Trust Fund dwindled. Separately, senators said Tuesday that they are nearing an agreement on a plan to replenish the highway fund. Senate Finance Committee Chairman Ron Wyden (D-Ore.) and Sen. Thomas Carper (D-Del.)…declined to specify the parameters of their emerging plan.” Ed O’Keefe and Ashley Halsey III in The Washington Post.
Primary source:
Need to get up to speed? See our previous coverage of this issue.
There’s one problem, though: Can negotiations get done in time? “The plan by House Ways and Means Committee Chairman Dave Camp, a Michigan Republican, would offset its costs by letting employers delay contributions to their employee pension plans, which raises corporate taxable income in a boon for the U.S. Treasury. It also would boost customs user fees and transfer $1 billion from a federal leaking underground storage trust fund. The proposal diverges from a plan in the Senate, complicating the ability to forestall a slowdown in disbursements from the highway trust to states next month.” Laura Litvan in Bloomberg.
And Ex-Im Bank renewal could be part of government funding bill. “High-level discussions between the two chambers are in their infancy….But there are forces in both chambers pushing to renew the Export-Import Bank and pass an extension of the Highway Trust Fund before the election. The House will go first, and plans to extend the Highway Trust Fund sometime in the next two weeks, keeping the program funded until early 2015, Republican sources said. That would give Congress more time to debate a more permanent solution….Senate Majority Leader Harry Reid (D-Nev.) is considering attaching a short-term reauthorization of the Export-Import Bank to a continuing resolution that would keep the government funded past Sept. 30.” John Bresnahan and Jake Sherman in Politico.
S&P issues warns on potential downgrades if Ex-Im renewal falls short. “Political infighting regarding renewal of the charter of a U.S. agency that provides customers of big American corporations with loans for their wares is beginning to have an effect on investor thinking. Standard & Poor’s Monday cautioned Boeing, the largest beneficiary by far of the Export-Import Bank, could face a weakening long-term credit rating should the bank lose its charter.” Greg Morcroft in International Business Times.
Democrats: The party of big business? Not so fast. “Democrats are seeing a new opportunity to rebuild frayed relations with business groups, whose traditional alliance with the Republican Party has been strained by tea-party opposition to rewriting immigration laws, a renewal of the Export-Import Bank and the pursuit of other business priorities….But Democratic outreach faces a big obstacle: Many business leaders, despite their frustrations with the GOP, have a hard time seeing a home in the Democratic Party, with its history of supporting tax increases and government regulation….Business groups in Washington find themselves in a tricky political situation, with anticorporate sentiment on the rise among elements of both parties.” Janet Hook in The Wall Street Journal.
Dancing interlude: Watch Tom Hanks dance to “This Is How We Do It” by Montell Jordan.
5. The NSA just had another bad day
Long read: Meet the Muslim-American leaders the FBI, NSA have been spying on. “Among the Americans on the list are individuals long accused of terrorist activity, including Anwar al-Awlaki and Samir Khan, who were killed in a 2011 drone strike in Yemen. But a three-month investigation by The Intercept…reveals that in practice, the system for authorizing NSA surveillance affords the government wide latitude in spying on U.S. citizens. The five Americans whose email accounts were monitored by the NSA and FBI have all led highly public, outwardly exemplary lives. All five vehemently deny any involvement in terrorism or espionage, and none advocates violent jihad or is known to have been implicated in any crime.” By Glenn Greenwald and Murtaza Hussain in The Intercept.
The government has asked Verizon for information 190,000 times, and it’s only July. “Verizon’s just published its second-ever transparency report, showing that in the first six months of 2014, the company received nearly 149,000 requests for customer data from the government. That’s fewer than the 160,000 times that federal, state and local law enforcement asked Verizon for information on its customers during a similar period in 2013. For the first time, Verizon’s described (albeit in pretty general terms) the number of Americans affected by each request. Of the more than 72,000 requests that came in the form of a subpoena during the first half of the year, 90 percent targeted three or fewer customers, according to the company.” Brian Fung in The Washington Post.
Senate panel advances cybersecurity information-sharing bill, but privacy advocates fear it would give more power to NSA. “The legislation includes provisions aimed at protecting privacy, such as requiring that companies that share information first strip out personally identifiable data (such as names, addresses, and Social Security numbers) of known Americans. But the privacy groups are still worried that the legislation could encourage a company such as Google to turn over vast batches of emails or other private data to the government. The information would go first to the Homeland Security Department, but could then be shared with the NSA or other intelligence agencies.” Brendan Sasso in National Journal.
Primary source: Financial services industry backs Senate bill.
- Published in Blog
Canadian Securities Exchange Added to OTC Markets Group’s list of “Qualified Foreign Exchanges”
CSE issuers now eligible to apply for trading on the OTCQX and OTCQB marketplaces
The Canadian Securities Exchange (“CSE”) today announced that the exchange has been included on the list of “Qualified Foreign Exchanges” by OTC Markets Group Inc. Starting immediately, interested CSE-listed companies are eligible to apply for trading on the OTCQX and OTCQB marketplaces operated by OTC Markets Group in the United States.
Richard Carleton, CEO of the CSE, commented: “We are extremely pleased with this move by our colleagues at OTC Markets Group. Eligible CSE-listed companies are now able to leverage their Canadian stock exchange listing with us to gain access to the largest public capital market in the world, expanding reach and liquidity opportunities. We look forward to working with our issuers and OTC Markets Group to increase investor access and visibility for our listed companies in the United States.”
James Black, VP of Listings Development at the CSE, added: “This additional benefit for CSE-listed companies comes on the heels of a record setting first quarter for the exchange – eclipsing previous bests for trading and listings on our listed marketplace. The addition of the CSE to the OTC Markets Group list addresses a longstanding desire for our issuers and further solidifies our value proposition for companies seeking a primary exchange listing in Canada.”
Jason Paltrowitz, Managing Director and Global Head of Business Development at OTC Markets Group Inc., also had the following remarks: “We are pleased to add CSE to our list of Qualified Foreign Exchanges. Our OTCQX and OTCQB marketplaces offer the best informed and most efficient trading for established and venture-stage international companies that are looking to increase their visibility with U.S. investors. We look forward to working with the CSE and CSE-listed companies to highlight these exciting Canadian investment opportunities in the U.S. market.”
FOR FURTHER INFORMATION PLEASE CONTACT:
Richard Carleton
CEO, CNSX Markets Inc.
416-367-7360
richard.carleton@thecse.com
About the Canadian Securities Exchange:
The Canadian Securities Exchange is the only exchange in Canada providing trading and market information services for all domestically listed instruments. Recognized as an exchange by the Ontario Securities Commission in 2004, the CSE is designed to facilitate the capital formation process for public companies through a streamlined approach to company regulation that emphasizes disclosure and the provision of efficient secondary market trading services for investors. The exchange is home to more than 200 issues covering a broad range of industry sectors.
- Published in Business
UPDATE – Lakeland Resources (LK.V) receives Star exploration review
Lakeland Resources Inc. Provides Update on 2014 Exploration
For the Star Property, Athabasca Basin
July 8, 2014 – Lakeland Resources Inc. (TSXv: LK) (FSE: 6LL) (the “Company” or “Lakeland”) is pleased to provide an update on exploration activities for the Star Property, located along the northern margin of the Athabasca Basin. The Star Property is directly adjacent to the Company’s Gibbons Creek Property and west of the community of Stony Rapids, Saskatchewan.
In preparation for the summer 2014 field program at the Star Property, the Company has received a review of historic and recent exploration from project consultants Dahrouge Geological Consulting Ltd. of Edmonton, AB; and notes the following:
Highlights
A one-day exploration program in 2013 found a number of surface grab samples enriched in gold, platinum group elements (PGE’s), and Rare Earth Element’s (REE’s); Two outcrop samples described as altered, black, cryptocrystalline and approximately 200 m apart contained highly anomalous concentrations of gold and PGE’s, as follow: Sample 79441: 1.8 g/t Au, 0.08 g/t Pt; 0.12 g/t PdSample 79447: 5.7 g/t Au; 0.36 g/t Pt; 0.39 g/t Pd A sandstone boulder with anomalous uranium values also contained strong enrichment in heavy rare earth elements; while a nearby outcrop contained 6.9{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} TREO’s: Sample 79442 (boulder sample): 257 ppm Uranium, 0.3{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} TREO (includes 1,216 ppm Dy2O3 and 321 ppm Y2O3)Sample 79447 (outcrop sample): 6.9{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} TREO (dominantly Light REE enriched).
Project Geology and Target Potential
The Star Property covers a quasi-circular basement uplift along the northern margin of the Athabasca Basin, immediately north of the Company’s Gibbons Creek Property (under option to Declan Resources Inc.). This structural feature is considered an ideal location for the development of uranium occurrence’s associated with the unconformity or sub-unconformity of the Athabasca Basin.
A small portion of the uplifted basement outcrop on the Star Property was prospected with very promising results, as highlighted earlier. In total, 8 outcrop samples and 2 boulder samples were collected. The highly anomalous concentrations of gold (up to 5.7 g/t Au), platinum group elements (0.75 g/t PGE’s), rare earth elements (up to 6.9{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} TREO) and highly anomalous uranium; suggest the presence of a robust hydrothermal system.
The potential for such a regional hydrothermal system is demonstrated by intense alteration associated with historic uranium mineralization within the Gibbons Creek Property located immediately to the south. Within the Athabasca Basin, there are a number of projects where highly anomalous precious metals and/or rare earth elements occur in spatial relation to Uranium deposits and/or mineralization. Examples of such mineralization include the Nicholson Bay and Fish Hook Bay U-Au-PGE occurrences, and the MAW Zone- Wheeler River occurrences.
Preliminary mineralogical work on the REE-bearing samples includes SEM analysis (Scanning Electron Microscope); BSE analysis (Electron Back-Scatter Analysis); and EDS (Energy Dispersive Spectrometry) and reveals the following:
Sample #79442 – The Heavy REE values are from fine-grained xenotime. The modal mineralogy of the sample reveals primarily quartz, with xenotime (3.1{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce}) and about 1.3{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} kaolinite/illite clay. Diagenetic-Hydrothermal xenotime accumulations are known elsewhere in the Athabasca Basin region, and have been associated with some unconformity-style uranium deposits (McArthur River, Key Lake, McLean Lake and others).
Sample #79446 – The sample contains 23.6{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} monazite, with 16.75{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} kaolinite/illite clay.
According to Jonathan Armes, President and CEO of Lakeland Resources Ltd.:
“We are extremely excited about the noteworthy U-Au-PGE +/- REE occurrence identified at the Star Property, and are looking forward to completing a near term mapping and sampling program to determine the extent of the mineralization. In addition, the historic association and spatial relationship of these commodities with large uranium mineralizing systems bodes well for the ongoing Uranium exploration at the Star Property and our adjacent Gibbons Creek Project.”
About the Property
The Star Property benefits from historic exploration including modern geophysics and drilling completed by Star Minerals in 2005 to 2008; and work by Eldorado Nuclear in the 1970’s and 1980’s. The Property is considered highly prospective for U, Au, PGE’s and REE mineralization. It also benefits from nearby infrastructure, with power lines and highways nearby.
Lakeland has the right to earn a 100{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} interest in the Star Property by making cash payments totaling $60,000 and issuing 600,000 common shares over a 12 month period. The Vendor will retain the option of a 25{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} buyback for 4 times the exploration monies spent by the Purchaser to the date that the buyback option is exercised. The buyback option will be exercisable at any time up to a 90 day period following the completion and publication of a 43-101 compliant resource estimate
NI 43-101 Disclosure
The technical information above has been prepared in accordance with the Canadian regulatory requirements set out in National Instrument 43-101 and reviewed on behalf of the company by Neil McCallum, P.Geo., of Dahrouge Geological Consulting Ltd., a qualified person.
Analytical Methods
All rock samples were delivered to Activation Laboratories Ltd., an ISO Certified Laboratory. All samples were analyzed by a 39-element “partial digestion” with ICP-MS/ICP-OES analysis; and a 49-element “total digestion” with ICP-MS/ICP-OES analysis. Uranium values are converted to U3O8 values with the conversion factor of 1.1792.
Samples with high REE values were tested using the 8-REE method whereby the sample is treated with lithium metaborate/tetraborate fusion with subsequent analysis by ICP-MS and ICP/MS analysis. All REE samples reported herein were derived using this method. Total Rare Earth Oxides (“TREO”) include: La2O3, Ce2O3, Pr2O3, Nd2O3, Sm2O3, Eu2O3, Gd2O3, Tb2O3, Dy2O3, Ho2O3, Er2O3, Tm2O3, Yb2O3, Lu2O3, and Y2O3.
All samples were tested using the 1C-OES-Exploration method Fire Assay (with Platinum and Palladium) on a 30 gram aliquot with an ICP finish.
About Lakeland Resources Inc.
Lakeland Resources Inc. is a pure play uranium exploration company focused on the Athabasca Basin in Saskatchewan, Canada; home to some of the world’s largest and richest high-grade uranium deposits. The Company’s common shares trade on the TSX Venture Exchange under the symbol “LK” and on the Frankfurt Stock Exchange under the symbol “6LL”.
For more information, please visit the corporate website at http://www.lakelandresources.com or contact Roger Leschuk, Corporate Communications at Ph: 604.681.1568 or TF: 1.877.377.6222 or email: roger@lakelandresources.com
On Behalf of the Board of Directors
LAKELAND RESOURCES INC.
“Jonathan Armes”
Jonathan Armes
President, CEO and Director
Cell: 416.708.0243
Ph: 604.681.1568
TF: 1.877.377.6222
Email: jarmes@lakelandresources.com
Web: http://www.lakelandresources.com
- Published in Mining
Marijuana Sector Positioned to Move Higher as FDA Reviews Drug’s Status
Jun 30, 2014 (ACCESSWIRE via COMTEX) — WHITEFISH, MT / June 30, 2014 / The Marijuana Index(TM) traded marginally lower last week after MedBox Inc. MDBX -2.31{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} and CannaVEST Corp.’s CANV -16.40{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} moves lower offset GW Pharmaceuticals plc’s GWPH -7.95{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} modest gains.
Top gainers included Tauriga Sciences Inc. TAUG -8.18{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} , which jumped more than 60{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} after saying that it remains on track with its Honeywood acquisition to commercial products in the medicinal cannabis sector, and Vape Holdings Inc. VAPE -7.69{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} , which jumped more than 40{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} after reporting results from the soft launch of its e-commerce website HiveCeramics.com last week. The largest decliners included Easton Pharmaceuticals Inc. EAPH -10.67{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} , which fell nearly 20{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} last week.
Cannabis regulatory initiatives and news were mixed last week. While the United Nations warned about a rise in cannabis-related medical cases following legalization efforts, the U.S. FDA indicated that it would reconsider marijuana’s status as a Schedule I Controlled Substance. Legalization efforts have also gained ground in many U.S. states, with Oregon and Alaska becoming two battlegrounds for recreational legalization efforts over the coming year.
What’s New?
– Cannabis Therapy Hemp Farm Measures Up – Cannabis Therapy Corp.’s CTCO -1.00{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} initial hemp cultivars are already well underway measuring in at 16 inches high with normal healthy growth characteristics.
– Cannabis Cultivation Strains Energy Grid – Cannabis cultivation could be putting a strain on the nation’s energy grid, leading some regulators and companies to come up with innovative solutions to the problem.
– A Junior GW Play in the Cannabis Industry – CannabisFN takes a closer look at Cannabis Technologies Inc. CANLF -1.82{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} (cse:CAN), which is being billed by many as a junior GW Pharmaceutials in the making.
– Debunking the Cannabis-Schizophrenia Link – Cannabis critics face a new argument that there may be a reverse association where schizophrenia may cause cannabis use rather than the other way around.
– Cannabis Tech to Begin Phase I Glaucoma Trials – Cannabis Technologies Inc. CANLF -1.82{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} (cse:CAN) announced the start of Phase I clinical trials of its CTI-085 topical cannabinoid therapy for the treatment of glaucoma.
– Abattis Secures Key International Patent – Abattis Bioceuticals Corp. ATTBF -5.21{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} recently secured an International Patent for refining the optimal natural sources of nitric oxide in the human body.
Exclusive Interview Series
In a recent episode of CannabisFN’s Executive Interview Series, Mike Elliott sits down to talk with Cannabis Technologies Inc. CEO Craig Schneider to discuss the company’s Cannabinoid Drug Design Platform and its plans to develop treatments to specific medical conditions utilizing cannabinoids.
Click Here: Watch the Full Interview
What to Watch This Week
The cannabis sector as a whole moved slightly lower last week, but a number of public companies in the space jumped higher. Traders and investors will continue to watch for positive regulatory developments, particularly as the FDA appears ready to review marijuana’s status as a Schedule I Controlled Substance. The removal of that marker could open up the door to new opportunities in the space.
Upcoming Events
– WeedStock Conference – June 29 to July 1, 2014 – The 1st Annual Cannabis Investor Conference in Denver, Colorado will feature networking events, industry speakers, expert panels, and more.
About CannabisFN
CannabisFN.com is a dedicated financial network covering new, emerging and established companies operating in the burgeoning multi-billion dollar medical marijuana (“MMJ”) and cannabis industries. CannabisFN’s coverage is syndicated on the leading industry specific and mainstream financial websites and social media. To learn more and request a media kit, visit http://www.cannabisfn.com/market-defining-companies-program/ .
To subscribe to the CannabisFN newsletter or read additional coverage on cannabis laws and investments, visit http://www.cannabisfn.com .
Disclaimer: Except for the historical information presented herein, matters discussed in this article contain forward-looking statements that are subject to certain risks and uncertainties that could cause actual results to differ materially from any future results, performance or achievements expressed or implied by such statements. Emerging Growth LLC dba TDM Financial, which owns CannabisFN, is not registered with any financial or securities regulatory authority, and does not provide nor claims to provide investment advice or recommendations to readers of this release. Emerging Growth LLC dba TDM Financial, which owns CannabisFN, may from time to time have a position in the securities mentioned herein and may increase or decrease such positions without notice. For making specific investment decisions, readers should seek their own advice. Emerging Growth LLC dba TDM Financial, which owns CannabisFN, may be compensated for its services in the form of cash-based compensation or equity securities in the companies it writes about, or a combination of the two. For full disclosure please visit: http://www.cannabisfn.com/legal-disclaimer/ .
SOURCE: Emerging Growth LLC
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Copyright 2014 ACCESSWIRE
- Published in Medical Marijuana
Canadian stock market plunges over telecom selloff
TORONTO, July 7 (Xinhua) — Canada’s main stock market Monday tumbled over telecom shares selloff, after the federal government announced that it plans to offer more market access for new wireless entrants.
Toronto Stock Exchange’s benchmark S&P/TSX Composite Index lost 42.03 points, or 0.28 percent to 15,172.93 points, as the losses in telecom and energy sectors overpowered the gains driven by the mining sectors.
The mining sector rose 1.61 percent after First Quantum Minerals Ltd. surged 3.63 percent to 25.95 Canadian dollars (about 24.30 U.S. dollars) and the Info-tech sector gained 0.80 percent with Canada’s smartphone BlackBerry jumping 5.63 percent to 12.01 Canadian dollars. However, the market was weighed when telecom closed down 0.99 percent, leading the losers after Canada’s Industry Minister James Moore announced on Monday that the government is to release more valuable spectrum to strengthen competition in Canada’s wireless industry, and the government will again tailor the next auction of the AWS-3 wireless spectrum, which is ideal for delivering fast, reliable service to Canadians on the latest smartphones, tablets and mobile devices.
The shares of major communication giants lost ground over the announcement. Rogers Communications Inc. declined 1.53 percent to 42.36 Canadian dollars, Telus dived 1.63 percent to 39.28 Canadian dollars, and Manitoba Telecom Services Inc. was also down 0.32 percent to 30.80 Canadian dollars.
The energy sector decreased 0.92 percent as the global crude oil price went down. Encana Corp. vapored 2.5 percent to 23.8 Canadian dollars and Surge Energy Inc. dived 2.92 percent to 7.64 Canadian dollars per share.
Another loser, Industrials, fell 0.76 percent with Air Canada down 1.99 percent to 9.85 Canadian dollars.
The real estate stock Canadian Apartment Properties increased 1. 06 percent to 22.90 Canadian dollars apiece as Statistics Canada Monday released the data showing that Canada’s municipalities issued building permits worth 6.9 billion Canadian dollars in May, up 13.8 percent from April.
On the currency front, the Canadian dollar Monday closed lower to 0.9366 U.S. dollar from 0.9384 U.S. dollar on last Friday.
- Published in Blog
Cannabis and Cannabinoids
Cannabinoids are a group of 21-carbon–containing terpenophenolic compounds produced uniquely by Cannabis species (e.g., Cannabis sativa L.) .[1,2] These plant-derived compounds may be referred to as phytocannabinoids. Although delta-9-tetrahydrocannabinol (THC) is the primary psychoactive ingredient, other known compounds with biologic activity are cannabinol, cannabidiol (CBD), cannabichromene, cannabigerol, tetrahydrocannabivarin, and delta-8-THC. CBD, in particular, is thought to have significant analgesic and anti-inflammatory activity without the psychoactive effect (high) of delta-9-THC.
One study in mice and rats suggested that cannabinoids may have a protective effect against the development of certain types of tumors.[3] During this 2-year study, groups of mice and rats were given various doses of THC by gavage. A dose-related decrease in the incidence of hepatic adenoma tumors and hepatocellular carcinoma (HCC) was observed in the mice. Decreased incidences of benign tumors (polyps and adenomas) in other organs (mammary gland, uterus, pituitary, testis, and pancreas) were also noted in the rats. In another study, delta-9-THC, delta-8-THC, and cannabinol were found to inhibit the growth of Lewis lung adenocarcinoma cells in vitro and in vivo .[4] In addition, other tumors have been shown to be sensitive to cannabinoid-induced growth inhibition.[5–8]
Cannabinoids may cause antitumor effects by various mechanisms, including induction of cell death, inhibition of cell growth, and inhibition of tumor angiogenesis invasion and metastasis.[9–12] Two reviews summarize the molecular mechanisms of action of cannabinoids as antitumor agents.[13,14] Cannabinoids appear to kill tumor cells but do not affect their nontransformed counterparts and may even protect them from cell death. These compounds have been shown to induce apoptosis in glioma cells in culture and induce regression of glioma tumors in mice and rats. Cannabinoids protect normal glial cells of astroglial and oligodendroglial lineages from apoptosis mediated by the CB1 receptor.[15]
The effects of delta-9-THC and a synthetic agonist of the CB2 receptor were investigated in HCC.[16] Both agents reduced the viability of HCC cells in vitro and demonstrated antitumor effects in HCC subcutaneous xenografts in nude mice. The investigations documented that the anti-HCC effects are mediated by way of the CB2 receptor. Similar to findings in glioma cells, the cannabinoids were shown to trigger cell death through stimulation of an endoplasmic reticulum stress pathway that activates autophagy and promotes apoptosis. Other investigations have confirmed that CB1 and CB2 receptors may be potential targets in non-small cell lung carcinoma [17] and breast cancer.[18]
An in vitro study of the effect of CBD on programmed cell death in breast cancer cell lines found that CBD induced programmed cell death, independent of the CB1, CB2, or vanilloid receptors. CBD inhibited the survival of both estrogen receptor–positive and estrogen receptor–negative breast cancer cell lines, inducing apoptosis in a concentration-dependent manner while having little effect on nontumorigenic, mammary cells.[19]
CBD has also been demonstrated to exert a chemopreventive effect in a mouse model of colon cancer.[20] In the experimental system, azoxymethane increased premalignant and malignant lesions in the mouse colon. Animals treated with azoxymethane and CBD concurrently were protected from developing premalignant and malignant lesions. In in vitro experiments involving colorectal cancer cell lines, the investigators found that CBD protected DNA from oxidative damage, increased endocannabinoid levels, and reduced cell proliferation. In a subsequent study, the investigators found that the antiproliferative effect of CBD was counteracted by selective CB1 but not CB2 receptor antagonists, suggesting an involvement of CB1 receptors.[21]
Another investigation into the antitumor effects of CBD examined the role of intercellular adhesion molecule-1 (ICAM-1).[12] ICAM-1 expression has been reported to be negatively correlated with cancer metastasis. In lung cancer cell lines, CBD upregulated ICAM-1, leading to decreased cancer cell invasiveness.
In an in vivo model using severe combined immunodeficient mice, subcutaneous tumors were generated by inoculating the animals with cells from human non-small cell lung carcinoma cell lines.[22] Tumor growth was inhibited by 60{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} in THC-treated mice compared with vehicle-treated control mice. Tumor specimens revealed that THC had antiangiogenic and antiproliferative effects. However, research with immunocompetent murine tumor models has demonstrated immunosuppression and enhanced tumor growth in mice treated with THC.[23,24]
In addition, both plant-derived and endogenous cannabinoids have been studied for anti-inflammatory effects. A mouse study demonstrated that endogenous cannabinoid system signaling is likely to provide intrinsic protection against colonic inflammation.[25] As a result, a hypothesis that phytocannabinoids and endocannabinoids may be useful in the risk reduction and treatment of colorectal cancer has been developed.[26–29]
CBD may also enhance uptake of cytotoxic drugs into malignant cells. Activation of the transient receptor potential vanilloid type 2 (TRPV2) has been shown to inhibit proliferation of human glioblastoma multiforme cells and overcome resistance to the chemotherapy agent carmustine.[30] In an in vitro model, CBD increased TRPV2 activation and increased uptake of cytotoxic drugs, leading to apoptosis of glioma cells without affecting normal human astrocytes. This suggests that coadministration of CBD with cytotoxic agents may increase drug uptake and potentiate cell death in human glioma cells.
Many animal studies have previously demonstrated that delta-9-THC and other cannabinoids have a stimulatory effect on appetite and increase food intake. It is believed that the endogenous cannabinoid system may serve as a regulator of feeding behavior. The endogenous cannabinoid anandamide potently enhances appetite in mice.[31] Moreover, CB1 receptors in the hypothalamus may be involved in the motivational or reward aspects of eating.[32]
Understanding the mechanism of cannabinoid-induced analgesia has been increased through the study of cannabinoid receptors, endocannabinoids, and synthetic agonists and antagonists. The CB1 receptor is found in both the central nervous system (CNS) and in peripheral nerve terminals. Similar to opioid receptors, increased levels of the CB1 receptor are found in regions of the brain that regulate nociceptive processing.[33] CB2 receptors, located predominantly in peripheral tissue, exist at very low levels in the CNS. With the development of receptor-specific antagonists, additional information about the roles of the receptors and endogenous cannabinoids in the modulation of pain has been obtained.[34,35]
Cannabinoids may also contribute to pain modulation through an anti-inflammatory mechanism; a CB2 effect with cannabinoids acting on mast cell receptors to attenuate the release of inflammatory agents, such as histamine and serotonin, and on keratinocytes to enhance the release of analgesic opioids has been described.[36–38] One study reported that the efficacy of synthetic CB1- and CB2-receptor agonists were comparable with the efficacy of morphine in a murine model of tumor pain.[39]
- Adams IB, Martin BR: Cannabis: pharmacology and toxicology in animals and humans. Addiction 91 (11): 1585-614, 1996. [PUBMED Abstract]
- Grotenhermen F, Russo E, eds.: Cannabis and Cannabinoids: Pharmacology, Toxicology, and Therapeutic Potential. Binghamton, NY: The Haworth Press, 2002.
- National Toxicology Program: NTP toxicology and carcinogenesis studies of 1-trans-delta(9)-tetrahydrocannabinol (CAS No. 1972-08-3) in F344 rats and B6C3F1 mice (gavage studies). Natl Toxicol Program Tech Rep Ser 446 (): 1-317, 1996. [PUBMED Abstract]
- Bifulco M, Laezza C, Pisanti S, et al.: Cannabinoids and cancer: pros and cons of an antitumour strategy. Br J Pharmacol 148 (2): 123-35, 2006. [PUBMED Abstract]
- Sánchez C, de Ceballos ML, Gomez del Pulgar T, et al.: Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor. Cancer Res 61 (15): 5784-9, 2001. [PUBMED Abstract]
- McKallip RJ, Lombard C, Fisher M, et al.: Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. Blood 100 (2): 627-34, 2002. [PUBMED Abstract]
- Casanova ML, Blázquez C, Martínez-Palacio J, et al.: Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J Clin Invest 111 (1): 43-50, 2003. [PUBMED Abstract]
- Blázquez C, González-Feria L, Alvarez L, et al.: Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. Cancer Res 64 (16): 5617-23, 2004. [PUBMED Abstract]
- Guzmán M: Cannabinoids: potential anticancer agents. Nat Rev Cancer 3 (10): 745-55, 2003. [PUBMED Abstract]
- Blázquez C, Casanova ML, Planas A, et al.: Inhibition of tumor angiogenesis by cannabinoids. FASEB J 17 (3): 529-31, 2003. [PUBMED Abstract]
- Vaccani A, Massi P, Colombo A, et al.: Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism. Br J Pharmacol 144 (8): 1032-6, 2005. [PUBMED Abstract]
- Ramer R, Bublitz K, Freimuth N, et al.: Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. FASEB J 26 (4): 1535-48, 2012. [PUBMED Abstract]
- Velasco G, Sánchez C, Guzmán M: Towards the use of cannabinoids as antitumour agents. Nat Rev Cancer 12 (6): 436-44, 2012. [PUBMED Abstract]
- Cridge BJ, Rosengren RJ: Critical appraisal of the potential use of cannabinoids in cancer management. Cancer Manag Res 5: 301-13, 2013. [PUBMED Abstract]
- Torres S, Lorente M, Rodríguez-Fornés F, et al.: A combined preclinical therapy of cannabinoids and temozolomide against glioma. Mol Cancer Ther 10 (1): 90-103, 2011. [PUBMED Abstract]
- Vara D, Salazar M, Olea-Herrero N, et al.: Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy. Cell Death Differ 18 (7): 1099-111, 2011. [PUBMED Abstract]
- Preet A, Qamri Z, Nasser MW, et al.: Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis. Cancer Prev Res (Phila) 4 (1): 65-75, 2011. [PUBMED Abstract]
- Nasser MW, Qamri Z, Deol YS, et al.: Crosstalk between chemokine receptor CXCR4 and cannabinoid receptor CB2 in modulating breast cancer growth and invasion. PLoS One 6 (9): e23901, 2011. [PUBMED Abstract]
- Shrivastava A, Kuzontkoski PM, Groopman JE, et al.: Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy. Mol Cancer Ther 10 (7): 1161-72, 2011. [PUBMED Abstract]
- Aviello G, Romano B, Borrelli F, et al.: Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer. J Mol Med (Berl) 90 (8): 925-34, 2012. [PUBMED Abstract]
- Romano B, Borrelli F, Pagano E, et al.: Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol. Phytomedicine 21 (5): 631-9, 2014. [PUBMED Abstract]
- Preet A, Ganju RK, Groopman JE: Delta9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo. Oncogene 27 (3): 339-46, 2008. [PUBMED Abstract]
- Zhu LX, Sharma S, Stolina M, et al.: Delta-9-tetrahydrocannabinol inhibits antitumor immunity by a CB2 receptor-mediated, cytokine-dependent pathway. J Immunol 165 (1): 373-80, 2000. [PUBMED Abstract]
- McKallip RJ, Nagarkatti M, Nagarkatti PS: Delta-9-tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the antitumor immune response. J Immunol 174 (6): 3281-9, 2005. [PUBMED Abstract]
- Massa F, Marsicano G, Hermann H, et al.: The endogenous cannabinoid system protects against colonic inflammation. J Clin Invest 113 (8): 1202-9, 2004. [PUBMED Abstract]
- Patsos HA, Hicks DJ, Greenhough A, et al.: Cannabinoids and cancer: potential for colorectal cancer therapy. Biochem Soc Trans 33 (Pt 4): 712-4, 2005. [PUBMED Abstract]
- Liu WM, Fowler DW, Dalgleish AG: Cannabis-derived substances in cancer therapy–an emerging anti-inflammatory role for the cannabinoids. Curr Clin Pharmacol 5 (4): 281-7, 2010. [PUBMED Abstract]
- Malfitano AM, Ciaglia E, Gangemi G, et al.: Update on the endocannabinoid system as an anticancer target. Expert Opin Ther Targets 15 (3): 297-308, 2011. [PUBMED Abstract]
- Sarfaraz S, Adhami VM, Syed DN, et al.: Cannabinoids for cancer treatment: progress and promise. Cancer Res 68 (2): 339-42, 2008. [PUBMED Abstract]
- Nabissi M, Morelli MB, Santoni M, et al.: Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents. Carcinogenesis 34 (1): 48-57, 2013. [PUBMED Abstract]
- Mechoulam R, Berry EM, Avraham Y, et al.: Endocannabinoids, feeding and suckling–from our perspective. Int J Obes (Lond) 30 (Suppl 1): S24-8, 2006. [PUBMED Abstract]
- Fride E, Bregman T, Kirkham TC: Endocannabinoids and food intake: newborn suckling and appetite regulation in adulthood. Exp Biol Med (Maywood) 230 (4): 225-34, 2005. [PUBMED Abstract]
- Walker JM, Hohmann AG, Martin WJ, et al.: The neurobiology of cannabinoid analgesia. Life Sci 65 (6-7): 665-73, 1999. [PUBMED Abstract]
- Meng ID, Manning BH, Martin WJ, et al.: An analgesia circuit activated by cannabinoids. Nature 395 (6700): 381-3, 1998. [PUBMED Abstract]
- Walker JM, Huang SM, Strangman NM, et al.: Pain modulation by release of the endogenous cannabinoid anandamide. Proc Natl Acad Sci U S A 96 (21): 12198-203, 1999. [PUBMED Abstract]
- Facci L, Dal Toso R, Romanello S, et al.: Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide. Proc Natl Acad Sci U S A 92 (8): 3376-80, 1995. [PUBMED Abstract]
- Ibrahim MM, Porreca F, Lai J, et al.: CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids. Proc Natl Acad Sci U S A 102 (8): 3093-8, 2005. [PUBMED Abstract]
- Richardson JD, Kilo S, Hargreaves KM: Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors. Pain 75 (1): 111-9, 1998. [PUBMED Abstract]
- Khasabova IA, Gielissen J, Chandiramani A, et al.: CB1 and CB2 receptor agonists promote analgesia through synergy in a murine model of tumor pain. Behav Pharmacol 22 (5-6): 607-16, 2011. [PUBMED Abstract]
- Published in Blog
Modest Gain for TSX to close strong week
Industrials and telecoms led the way to a minor advance Friday on the Toronto stock market at the end of a positive week. Canada’s main stock market closed at another record high as the S&P/TSX composite index rose 7.85 points to 15,214.96. Trading was much lighter than usual with U.S. markets closed for the Independence Day holiday. The Canadian dollar edged down US0.15¢ to US93.84¢.
The Toronto market racked up a solid weekly gain of 120.71 points, or 0.8{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce}, led by mining and financial stocks after U.S. jobs data for June, released Thursday, came in far higher than expected. The report also increased optimism that the U.S. economy will rebound significantly after shrinking in the first quarter.
The Dow Jones industrial average finished the week up 1.28{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} and closed above the 17,000-mark for the first time.
The strong U.S. jobs data is the latest piece of data to show the world’s biggest economy continues to improve steadily. Also helping stocks are solid corporate earnings and continued support from central banks. Traders are now focused on the start of U.S. second-quarter earnings reports for reassurance about how the economy performed in the April-June period. Heavyweights reporting next week include Alcoa Inc. and Wells Fargo & Co.
At the same time, analysts note expectations for the quarter are rather modest.
“OK, but not spectacular,” said Bob Gorman, chief portfolio strategist at TD Waterhouse, in describing them. “Firms have been lowering expectations, so that may bring some of the very strong sentiment down to Earth a bit.”
The industrials sector was the biggest percentage advancer, up 0.6{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce}. Telecoms also provided lift, ahead 0.42{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce}.
Commodity prices were mixed in electronic trading on the New York Mercantile Exchange with August bullion US70¢ higher late Friday afternoon at US$1,321.30 an ounce. The gold sector gained 0.15{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce}.
The base metals sector was the biggest decliner, down 0.55{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} while September copper was off US1¢ at US$3.27 a pound.
The energy sector declined 0.36{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce} as August crude moved US29¢ lower to US$103.77 a barrel. On the corporate front, Lassonde Industries Inc. is acquiring U.S. branded juice company Apple & Eve LLC for US$150-million in a bid to strengthen its presence in the United States. Lassonde shares ran ahead $9.14, or 8.32{92d3d6fd85a76c012ea375328005e518e768e12ace6b1722b71965c2a02ea7ce}, to $119.
Shaw Media is making plans to launch a national TV news channel called Global News 1. In filings to the Canadian Radiotelevision and Telecommunications Commission, the media division of Shaw Communications Inc., which operates Global Television, says it wants to launch a “hybrid local/national” English-language news channel. Shaw shares were 16¢ lower at $27.62.
Several cars in a Canadian National Railway Co. freight train have derailed northwest of Edmonton. Two of the five cars were carrying crude oil. There were no injuries and no fire when the cars left the tracks early Friday morning. CN shares were up 42¢ to $70.02.
- Published in Blog